David Hart, PhD
Inflammatory processes are critical for many aspects of host defense, are involved in the healing response to injury and contribute to pathologic sequelae (autoimmune diseases, cystic fibrosis, etc.). We are interested in the regulation of components of these processes, particularly proteinases and their inhibitors. By better understanding these processes and components, it may be possible to enhance their influence in some circumstances (healing, host defense) and negate their influence in circumstances detrimental to the host (inflamamatory lung and joint diseases).
The laboratory uses the tools of molecular and cell biology to study both in vitro and in vivo animal models of inflammation. Through collaborations with a number of Clinical Scientists, we also focus on various aspects of human disease whenever possible.